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It is synthesized as a proreceptor that is cleaved into alpha and beta chains and assembled into a covalent heterotetramer, two alpha subunits and two beta subunits held together by disulfide bonds, which sits in the membrane as a preformed dimer even in the absence of ligand
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SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease
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This could be due to medical conditions like pernicious anemia or digestive disorders such as Crohns disease or celiac disease
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