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As chronic PE induces tissue changes that go beyond skeletal muscle tissue (e.g., increase in mitochondria in adipose tissue), it is plausible that changes such as improvement in mitochondrial metabolism (improves their structure and function) in the epidermis also could occur in response to physical training practice (see Figure 6)
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Selenium, antioxidants, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials
Alexander Weber, an orthopedic surgeon and chief of sports medicine at the University of Southern California who has published a review of the evidence
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