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Therefore, there are multiple factors to consider when outlining the biggest differences between the two melanocortin agonists: Molecular Structure: While both MT1 and MT2 are synthetic analogs of alpha-MSH, they have only four amino acids in common: the sequence His-D-Phe-Arg-Trp (positions three to six in MT2)

Germline TERT promoter mutations are rare in familial melanoma

Water Retention and Joint Pain: Excess GH can cause mild edema or joint aches in some individuals

Notably, iCAFs were enriched in immune-regulatory genes and were shown to express immune checkpoint molecules including PD-L1, contributing to T-cell dysfunction and immune exclusion (145)