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Neutrophils contribute to RA in various ways: (I) they possess a pool of highly toxic proteases that are released at sites of inflammation (II) activated neutrophils can secrete a variety of pro-inflammatory cytokines and chemokines, causing subsequent inflammation (III) activated neutrophils form neutrophil extracellular traps, which contain externalized citrulline proteins as a source of modified autoantigens for the production of ACPAs [7]

IT IS IMPORTANT that you keep all doctor and laboratory appointments while you are using this medicine

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