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However, overlap exists in downstream effects on glucose and lipid metabolism, meaning additive effects are possible but not guaranteed for every person

In a subsequent prospective cohort, liraglutide not only improved metabolic parameters but also demonstrated immunomodulatory effects, with a significant reduction in circulating T-cell populations, particularly T cells, which are known to play a key role in PsO pathogenesis by producing IL17 and IL22 ( Successive case reports confirmed the beneficial effects of liraglutide in obese PsO patients without T2DM (52), and a subsequent trial demonstrated marked improvements in PsO symptoms within a few days of treatment, regardless of significant weight loss (50), a result which was later confirmed in other studies (53, 54)

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Behav Brain Res 155:77-84