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Improper storage could lead to vitamin degradation (losing potency) or increased risk of injection site reactions (if contaminants or precipitates form), so patients and providers should take the storage guidelines seriously

Key pathways such as PI3K/AKT/mTOR (PAM), RAS/RAF/MEK/ERK [22], and Notch are frequently activated in GBM, promoting cell proliferation, survival, and invasion, while also contributing to the resistance of GBM cells to chemotherapy and radiation therapy

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Whilst berberine may offer modest metabolic benefits through various mechanisms, it should not be viewed as a replacement for evidence-based medical treatments or lifestyle modifications that form the cornerstone of metabolic disease management