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[PubMed] [Springer] 97

How Virtual Weight Loss Care Works 1

During T2D development, chronic overnutrition interferes with insulin signaling leading to decreases in insulin sensitivity

The conversation covers how our understanding of obesity as a chronic, relapsing disease has changed over the past 30 years, what the new clinical versus preclinical obesity framework means for how we diagnose and treat it, how GLP-1 drugs work and why they've succeeded where earlier medications failed, what the STEP and SELECT trials revealed about the disease-modifying potential of semaglutide, and how patients and clinicians should be thinking about who these drugs are really for