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Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase i inhibitors via cooperative modulation of hypoxia-inducible factor-1
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However, administration of the ferroptosis inhibitor ferrostatin-1 has been shown to suppress lipid peroxidation, restore GSH levels, reduce iron accumulation, and markedly attenuate neuronal death (63), suggesting that targeting ferroptosis could provide therapeutic benefits in HD
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