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1 Reference intakes for the average adult according to VO (EU) 1169/2011 (in %)

Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms

The use of GLP-1R agonists was associated with fewer intra-articular injections of steroids and a lower cartilage loss velocity from the medial femoral joint, but the direct effects of GLP-1R agonist, apart from the weight loss-mediated pathway, did not reach statistical significance