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Its Not Recommended by Either the FDA or the Drug Maker Both the US Food and Drug Administration (FDA) and Novo Nordisk, the maker of Wegovy and Ozempic, have warned against splitting semaglutide doses exactly for the reasons weve outlined above: its not sterile, it introduces too much room for error, and it can increase the risk of side effects
Common approaches include 4 weeks on followed by 2 weeks off, 6 weeks on followed by 4 weeks off, or running continuously until the injury resolves and then stopping
Most individuals can tolerate them and gain their benefits, except for the few individuals who drop the medication for gastrointestinal side effects (~ 4%) or those who dont achieve adequate therapeutic benefit (10% 23% do not achieve 10% weight loss for tirzepatide and semaglutide, respectively)
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