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Following phosphorylation, MLKL oligomerizes and a small part of these oligomers moves towards the cell membrane where they mediate their effect in two different ways, either directly by facilitating the formation of pores across the cell membrane mediated through binding to membrane phospholipids like phosphatidylinositol phosphate and cardiolipin or indirectly by increasing influx of ions (Na + , K + , Mg 2+ , and Ca 2+ ) through recruitment of cation channels and Ca 2+ channels, the transient receptor potential melastatin related 7 (TRPM7), thereby increasing osmotic pressure and eventually leading to cell rupture (vanden Berghe et al., 2016

In China, for instance, 3 years after the introduction of salt iodisation in 1996, the prevalence of AITD was 05 % in an area of mildly deficient iodine intake, 17 % in an area of more-than-adequate iodine intake and 28 % in an area of excessive iodine intake ( Reference Teng, Shan and Teng 14 )

It also has a strong research base, with studies looking at how it interacts with cell signaling and the extracellular matrix (Pickart & Margolina, 2018)

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