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It is included on the 2026 WADA Monitoring Program, which tracks markers of semaglutide and tirzepatide use across sports without imposing sanctions
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These agonists stimulate the AMPK pathway, leading to the activation of Sirtuin 1 (SIRT1), a NAD + -dependent deacetylase that upregulates the expression of lipolytic proteins like triacylglycerol lipase
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