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Human data remain limited to case reports, so efficacy in clinical practice is still under evaluation

Sulfonylurea drugs affect sulfonylurea receptor 1 (SUR 1), which leads to the closure of adenosine triphosphate (ATP)-dependent potassium channels, preventing potassium from leaving the cell and depolarizing the cell membrane, leading to an influx of calcium and triggering insulin release

Although different pathophysiological mechanisms lead to metabolic syndrome, it is associated with obesity through dysfunction of adipose tissue as the main contributor to obesity and subsequent complications