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Incretin-based dual agonist therapy may offer an alternative to stringent dietary restriction and challenge the success of bariatric surgery in the diabesity community INTRODUCTION The incretin effect, an augmented prandial insulin response, is mediated mostly by the hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), which are released from the intestines after meals
Melanotan 2 and PT-141 share the same biological root, the melanocortin system, and the latter is even a direct descendant of the former
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