As a Black woman in the public eye, Williams has always faced a disproportionate level of scrutiny over her body her musculature, her curves, her clothing choices scrutiny that her white peers rarely endured in both volume and scale
The short version is that weight loss on Retatrutide begins within the first few weeks, accelerates sharply between months 3 and 6, and gradually tapers off as you approach the 10 to 12 month mark
But the dose-response data strongly suggests that peak concentration, not just total exposure, matters for glucagon receptor activation

Weight loss peptides (GLP-1 agonists) Examples : Semaglutide, Tirzepatide, Liraglutide Common side effects (mostly GI-related): Nausea : Frequency: 40-50% of users initially Severity: Mild to moderate Duration: Usually 1-3 weeks (improves with continued use) Management: Start low dose, increase gradually, eat smaller meals Constipation : Frequency: 20-30% of users Severity: Mild to moderate Management: Increase fiber, water, consider stool softener Diarrhea : Frequency: 15-20% of users Severity: Mild Duration: Usually temporary Management: Probiotics, reduce fatty foods Fatigue : Frequency: 20-30% initially Severity: Mild to moderate Duration: 2-4 weeks (improves as caloric deficit stabilizes) Management: Adequate protein, electrolytes, patience Reduced appetite (intended effect): Not a side effect - this is the mechanism Goal: 15-20% reduction in caloric intake Result: Weight loss Read our semaglutide vs tirzepatide comparison