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NNMT is upregulated in the white adipose tissue of obese animals and humans, and its activity is mechanistically linked to depleted cellular NAD+ and SAM pools

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By reducing NNMT catalytic activity, the compound allows researchers to evaluate how limiting nicotinamide methylation influences: In vitro and in vivo experimental models (non-clinical, non-human) have demonstrated that NNMT suppression leads to measurable changes in cellular energy markers and adipocyte behavior