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Published binding assays show PT-141's Ki for MC4R is approximately 0.9 nM, compared to 12 nM for MC1R, meaning it activates sexual arousal pathways at doses far below the threshold for melanogenesis

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Antidepressants : Tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) have not been clearly beneficial for individuals with ASD and are sometimes associated with side effects