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The use of GSH precursors like N-acetyl cysteine, enhancers of nuclear factor erythroid 2-related factor 2 (Nrf2) like sulforaphane, melatonin, and many more molecules involved in antioxidant defense were proposed as supplementation of other idiopathic pulmonary fibrosis therapies (130)

Research examines potential interactions between their absorption profiles, systemic biodistribution, and associated molecular responses in experimental tissue-remodeling models

For broader peptide side-effect management, see the peptide safety guide

However, base editing for FRDA treatment has off-target issues and requires future improvements