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The self-assembled Bacteriphage MS2 VLP, which is modified with SP94 peptide and encapsulated with doxorubicin, cisplatin, and 5-fluoro-uracil to selectively transport and kill human hepatocellular carcinoma (HCC) in the Hep3B cell line, is a classic example of VLPs as targeted therapeutic carriers (147)
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doi: 10.1016/S2213-8587(19)30180-9 47 MuskietM
However, the total drug exposure (measured as AUC) remains the same
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