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Through these interactions, GLP-1 and GLP-1RAs influence appetite and food intake but also reward mechanisms, which may be very important for the clinical effects of the agonists

The picture was dominated by anhedonia, flat motivation, and psychomotor slowinga hedonic, dopaminergic cluster sitting on top of what we suspected was a drug-induced mechanism

Three diabetes incretin medications are now approved for pediatric use starting at age 10 (see cheat sheet), and two incretin-based weight management medications are approved for children aged 12 and older

7 In patients with T2DM, the release of incretin hormones is physiologically insufficient, thereby compromising the ability to adequately secrete insulin and also execute other physiologic processes required to meet the metabolic requirements to maintain normoglycemia