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these findings may explain in part the limited nature of the metabolic improvements observed in response to pharmacologic intervention 2,10

Weight loss improves knee OA, with studies showing a 2% improvement in the WOMAC pain, function, and stiffness scores for every 1% reduction in body weight

[1] When combined, the cumulative effect on heart rate and blood pressure may be clinically significant, particularly in patients with pre-existing cardiovascular disease, uncontrolled hypertension, or arrhythmias

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