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When present, usually mild and transient

Diarrhea and colitis incidence in cases treated by PD-1/PD-L1 blockers are lower than ipilimumab treated cases: 11-19% and 1-4%

Clinicians should also avoid or adjust therapy in individuals with active peptic ulcer disease due to theoretical choline-mediated increases in gastric volume and in those receiving levodopa, as pantothenic-acid derivatives may interfere with levodopa absorption

Treatment was associated with fibrosis improvement by at least one stage with no worsening in non-alcoholic fatty liver disease (NAFLD) activity score in 25% of resmetirom recipients versus just under 15% in the placebo group