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The benefit is not hype
All three compounds in the GLP-1 drug class, including Retatrutide, Tirzepatide, and Semaglutide, activate this receptor
It is still the only such drug on the market
It has to be mentioned that KO mice for IGF-1 gene are not viable and studies in such mice have to be done in the first days of life, and thus results are not very conclusive as metabolism is not properly established at this stage [129, 228]
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