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whilst Melanotan 2 has been around for 20 years, the studies on its long-term use are limited

At a high level, what appears to be most tangible about the experience of patients on GLP-1s is an abrupt reduction in cravings and compulsive behaviors and a sense of increased agency: the ability to make conscious decisions about what to consume, whether it is food or other substances, rather than feeling pulled by a strong internal urge

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Because GLP-1 can lead to rapid and significant weight drops, in some cases, the amount of muscle lost can still be considerable if no countermeasures are taken