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The main differences are their licensed uses and dosing Wegovy is specifically approved for weight loss and reaches a higher maximum dose, while Ozempic is licensed for diabetes management in the UK
In clinical trials, retatrutide is being examined for its ability to assist with obesity, type 2 diabetes, metabolic dysfunction-associated steatohepatitis (MASH), chronic kidney disease, and cardiovascular risk reduction
Reported or theoretically plausible side effects of CJC 1295 and ipamorelin include: Water retention and peripheral oedema Flushing, headache, and dizziness, particularly after injection Tingling or numbness in the extremities Elevated IGF-1 levels, which over time may theoretically increase the risk of certain cancers, though a direct causal link has not been established in clinical studies [13] [14] Impaired glucose tolerance or insulin resistance GH excess and GH secretagogues are more commonly associated with raised blood glucose rather than hypoglycaemia
Further, the biotransformation can also occur in the absence of nutrients, as has been shown in studies with resting cells [14]
