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However, another placebo-controlled randomised controlled trial (RCT) using a higher dose of pioglitazone (3045 mg once a day for 12 weeks) in T2DM failed to find any improvement in maximal ATP synthesis measured using 31 P magnetic resonance spectroscopy [126] despite a decrease in intramyocellular lipids in the pioglitazone arm relative to placebo
One paper [26] reviewing diabetic neuropathy included two RCTs [10,28] and concluded that ALC could relief neuropathic pain, while another paper reviewing HIV-associated neuropathy included one RCT [11] and suggested no superiority of ALC to placebo
On the other hand, phentermine is a stimulant that suppresses appetite and boosts energy levels
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