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When estrogen levels drop during perimenopause and menopause, fibroblast activity slows dramatically, and collagen depletion speeds up in a way that becomes visible: sagging, thinning, increased dryness, more pronounced lines

4.2 Microglia-mediated oxidative neuronal injury Microglial activation initiates neuronal damage, and a previous study revealed that the microglial inhibitor minocycline reduces neuronal apoptosis ( in vivo oxidative stress (Yi et al., 2023)

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