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Description

Using Too Little Water Adding 0.5mL to a 5mg vial gives 10,000mcg/mL

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10.1021/bi001088w 29 NijhoutH

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The full 2.4mg therapeutic maximum sits at just 48 units, well under half the syringe capacity

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This relationship can be rationalized by the similar chemical mechanism, involving an aromatic nucleophilic attack by the sulfur of glutathione to form a Meisenheimer -complex, which is followed by the release of the common conjugate S-2,4-dinitrophenylglutathione

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