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To summarize several meta-analyses of CVOTs conducted with GLP-1RAs, it isconfirmed that based on 43 trials, GLP-1RAs are a class of efficacious agent for reducing MACE (MH-OR 0.87 [0.83, 0.92]), cardiovascular and all-cause mortality (MH-OR 0.89 [0.83, 0.96]) [48]
Moreover, only two drugs targeting insulin resistance are available, while there are many drugs targeting insulin secretion [164]
Once-weekly injectable formulations such as semaglutide and dulaglutide can be administered at any time of day, provided consistency is maintained
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