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[16], behavioral interventions typically lead to a 510% weight loss, while GLP-1 receptor agonists can result in an 821% reduction, and bariatric surgery achieves a weight loss of 2530%
Retatrutide's labeling in phase 2 excluded these patients explicitly [2]
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The medication then binds to GLP-1 receptors in the hypothalamus and brainstembrain regions controlling hunger signals and food intake
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