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96401/96402 for Chemotherapy and Hormonal Agents The most critical code-selection rule for procedure code 96372 is confirming that the drug administered is not a chemotherapy or hormonal antineoplastic agent: Non-hormonal chemotherapy agents (e.g., methotrexate for cancer, bleomycin) administered SC or IM CPT 96401 , not 96372 CPT code Hormonal antineoplastic agents (e.g., leuprolide acetate/Lupron, goserelin/Zoladex, degarelix) administered SC or IM CPT 96402 , not procedure code 96372 Note that methotrexate administered for rheumatoid arthritis or psoriasis (not cancer) may be reported under CPT code 96372 since it is used in that context as an immunosuppressant rather than a chemotherapy agent

The incidence varies by specific agent, dose, and individual patient factors

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