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As GLP-1 binds to GLP-1 receptors expressed on pancreatic cells, the receptors couple to G-protein subunits and activate adenylate cyclase, which increases the production of cAMP from ATP

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Patients with a history of severe cutaneous or other serious delayed-type reaction (eg, drug reaction with eosinophilia and systemic symptoms or Stevens-Johnson syndrome) to an antimicrobial sulfonamide should be cautioned to maintain lifelong avoidance

The glucagon receptor agonism is thought to play an important role in hepatic fat reduction: preclinical and early clinical data suggest that glucagon stimulates hepatic fatty acid oxidation and promotes lipid export from the liver, potentially reducing intrahepatic triglyceride content