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Ethics and dissemination National Health and Research Council, Nepal (NHRC 253/2016) and Regional Committee for Medical and Health Research Ethics of Western Norway (2016/1620/REK vest) have approved the study

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(ii) Cu 2+ induces the secretion of acidic SMase from leukocytes which in turn leads to accumulation of erythrocytic ceramide [131] and (iii) treatment of erythrocytes with extracellular SMase resulted in ceramide-associated alterations in membrane-cytoskeleton interactions and membrane organization [125]