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While this new study finds a more modest increase in NAION incidence than was reported in earlier studies, researchers continue to advocate for greater vigilance among healthcare providers prescribing GLP-1 receptor agonists like semaglutide, which is marketed under the brand names Ozempic, Wegovy, and Rybelsus
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The main mechanism of action of these GLP-1RA is the stimulation of the GLP-1R that triggers the activation of several metabolic pathways involved in insulin secretion, lipid metabolism, energy expenditure, pro-survival and anti-apoptotic cellular signaling, and oxidative stress prevention, in several tissues like the pancreas, central nervous system, heart, muscle, kidneys, gut, among others (15)
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