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Because MOTS-c enhances insulin-independent glucose uptake, patients with type 1 diabetes or those using exogenous insulin should be monitored carefully to prevent hypoglycemia, though this theoretical risk has not materialized in clinical reports to date

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Standard diabetes and weight management monitoring should continue as per NICE guidance, including HbA1c measurement, cardiovascular risk assessment, and monitoring for common GLP-1 adverse effects such as gastrointestinal symptoms

Weeks 1-4: Initiation and Adaptation The first month focuses on establishing consistent injection routines and allowing the body to adapt to elevated glutathione levels