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Summary of CV and Renal Outcomes with SGLT2i and DPP4i Agents SGLT2: Inhibitor Cardiovascular Outcome Trials Cardiovascular outcome trials (CVOTs) have consistently shown that treatment with SGLT2i reduces hospitalization for heart failure (HHF) and secondary renal outcomes in terms of incident or worsening nephropathy in patients with T2DM and CV disease
In addition, systematic reviews and meta-analyses of randomized controlled trials report improvements in cardiac systolic and diastolic function in patients with type 2 diabetes, as well as reductions in infarct size after myocardial infarction [163]
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