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There is no controlled human safety or efficacy data for the combination
The goal of this trial was to see whether in patients with overweight and obesity, who dont have diabetes, if their risk of cardiovascular events could be reduced by treatment with semaglutide, explained Michael Lincoff, MD, cardiologist for Cleveland Clinic
Phentermine has been used for short-term weight management (typically 12 weeks or less) since 1959, while GLP-1 agonists like Ozempic and Mounjaro gained obesity indication approval only in 2021 and 2023 respectively, backed by multi-year trial data
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