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True non-responders: uncertain outcomes If semaglutide produced absolutely no appetite suppression, no metabolic improvement, and no weight loss even at the maximum 2.4mg dose over 16 or more weeks, you may have fundamental resistance to GLP-1 receptor agonism
In preclinical research models, the timeline for metabolic response will depend on species, dose, and the specific endpoints being measured
Receptor mRNA expression ( Glp1r and Cckar ) was normalized to 36b4 mRNA levels
Figure 1 from Colhoun , et al, Nat Med 2024 Even if semaglutide saves lives, hearts, and kidneys, and FLOW is a global trial, implementation of the so-called fourth pillar remains a local challenge
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