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Semaglutide slows gastric emptying, which prolongs the sensation of fullness after meals and reduces appetite

Regul Pept 118:1118 Muscelli E, Mari A, Casolaro A et al (2008) Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients

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Therefore, the decrease in both the reaction rate and yield could be caused by a decrease in NsPCS activity