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In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]

If symptoms persist longer, consult a healthcare provider

Future research directions include direct comparative trials between various GLP-1 RAs and multi-agonists in MASLD populations to identify optimal therapeutic choices for specific patient subgroups