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No human clinical trials exist for TB-500
The peptide suppresses pro-inflammatory cytokines including TNF-, IL-6, and TGF-, which are key drivers of chronic low-grade inflammation (inflammaging) in older skin
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According to this study (137), it has been shown that in UC, the activation of the iNOS/COX-2/5-LOX loop and increased levels of their end products, such as NO, prostaglandin E2 (PGE2), and leukotriene B 4 (LTB 4), which lead to the overproduction of free radicals and the impairment of the antioxidative system
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