It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
The SELECT trial demonstrated cardiovascular benefit in patients with established heart disease, showing approximately 20% reduction in major adverse cardiovascular events
If youre taking or considering GLP-1 medications, understanding their potential impact on your eye health is crucial
Tissue factor (TF) is the initiating factor of coagulation extrinsic pathway, which expressed on cell membrane of mice and human hepatocytes (Kopec and Luyendyk, 2014)