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That is why G6PD-deficient RBCs are unable to withstand oxidative damage and are susceptible to destruction

then a 20 mg/kg dose (the typical therapeutic dose) produces a gut concentration of 6000 M, assuming 75% bioavailability

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Hauser, a physician known for treating many hypermobile EDS patients, has stated that studies on prolotherapy show pain relief in hEDS, and he points to research on temporomandibular joint (TMJ) disorders associated with EDS: prolotherapy injections to stabilize the TMJ have been shown to effectively reduce pain and jaw dislocations in those hypermobile joints