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(jofem.org) The best-case signal: modest weight loss in a shorter trial A frequently cited 12-week randomized trial result (as summarized in reviews) reported: ~2.6 kg average loss with AOD-9604 1 mg/day vs ~0.8 kg with placebo (PMC) This is the kind of result that can be statistically meaningful, clinically modest, and very sensitive to study design (diet, activity, baseline metabolic status, adherence)
Evangelisti S, Gramegna LL, La Morgia C, et al
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A large 2025 network meta-analysis assessed a wide range of nutritional supplements for women with infertility and found some promising signals, including a combination of probiotics and vitamin D for clinical pregnancy rates
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