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GHK-Cu is understood to upregulate collagen synthesis in dermal fibroblasts, a mechanism explored in multiple studies, including research on copper peptides and skin regeneration published in Biomolecules , which also examined GHK's broader gene-modulating effects

Beyond sequence, epigenetic evidence points to an NNMT-linked signature in human adipose tissue, indicating the pathway is dynamically active in human fat biology, not only in laboratory animals

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