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These drugs have since been linked to certain ocular effects, such as an increased risk of nonarteritic anterior ischemic optic neuropathy (NAION), which was demonstrated for the first time in a recent observational study
Here, we reveal that while the peptides form similar interactions in the fully active, G s -coupled state of the receptor, exendin-4 and oxyntomodulin-occupied receptors are more dynamic, which may, in part, be linked to the more transient nature of their interactions with the TMD observed in MD simulations
(Boston: Academic Press), 615633
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