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Formation of the NFT radical anion is required for Nrf2 activation As activation of Nrf2 requires the oxidation of critical sulfhydryl groups in its interaction partner, Keap1, we investigated the mechanism of this activation by NFT
140 Whereas the continuous supply of FeS clusters by NFS1 also prevented the iron-starvation response from being triggered in lung adenocarcinomas, NFS1 suppression was shown to predispose cancer cells to ferroptosis
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