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74 For instance, in the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial, weekly semaglutide administration resulted in a mean body weight reduction of 14.9% from baseline among overweight or obese non-diabetic individuals, 76 a magnitude of weight loss previously observed only following bariatric surgery

The challenge is that when you eat less overall, you may also eat less protein without realizing it

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Dose Response and Individual Variation in Tirzepatide Efficacy Clinical trial data demonstrates dose-dependent response: at 5 mg weekly, average weight loss was 15%