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In sepsis, Kupffer cells, the resident macrophages in the liver sinusoids, become activated and continue to synthesize pro-inflammatory factors (such as TNF-, IL-6, IL-18 and IL-1), secrete chemokines and leukotrienes, and initiate ROS and NO production
Elife 7 , e36158 (2018)
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Interpreting the Difference The 3.3 percentage point advantage for Retatrutide becomes more significant when translated to real-world outcomes
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