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The first peptide polyagonist that was officially approved for T2DM and obesity was tirzepatide (LY3298176), a dual GLP-1/GIP receptor agonist which is currently under investigation in RCTs for obesity and NAFLD [7]
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Nitric oxide signaling NO is a potent eryptosis suppressor (Fig
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![GLP-1 Weight-Loss Medication Glucagon-like peptide-1 (GLP-1) receptor agonists (semaglutide [Wegovy, Ozempic, Rybelsus]) and dual incretin agonists (tirzepatide [Zepbound, Mounjaro]) are popular treatments for obesity. The authors discuss the kind of](https://lookaside.fbsbx.com/lookaside/crawler/media/?media_id=1050961973852737)
